The Twins’ 2025 calendar includes the earliest Opening Day in team history. The Minnesota Twins have released their regular-season schedule for 2025, with the home opener against the Houston Astros on April 3. But that will be a week after the season begins on March 27 on the road against the St. Louis Cardinals.
The 2025 MLB season will begin March 18-19 with the Cubs playing the Dodgers in Tokyo. Minnesota opening March 27 in St. Louis will beat the previous record by one day. After three in St. Louis, the Twins will head to Chicago for three against the White Sox before returning to Minneapolis for the Home Opener April 3 against the Astros.
Overall, the Twins will play 10 of the first 13 games on the road.
Minnesota and Milwaukee will meet for the “border battle” series in Minneapolis June 20-22. ]
Other key home American League matchups include the Orioles (May 6-8), Blue Jays (June 6-8), Red Sox (July 28-30) and Yankees (September 15-17). Their key home National League matchups will be against the Mets (April 14-16), Cubs (July 8-10), Padres (August 29-31) and Diamondbacks (September 12-14).
